| SMITHVILLE (3-1) | AMORY (2-2) | HATLEY (0-4) | |||
| August 27 | Belmont L COVID | IAHS L 35-14 | at Hamilton L COVID | ||
| September 2 | at Hatley W 33-13 | Smithville L 33-13 | |||
| September 3 | at Caledonia L 30-18 | ||||
| September 10 | Hamilton W 31-0 | Mooreville W 51-21 | Mantachie L 32-0 | ||
| September 17 | at Alcorn Central W 33-20 | at North Pontotoc W 38-7 | at Belmont L 47-0 | ||
| September 24 | Ashland | Houston | at Holly Springs | ||
| October 1 | at Okolona | at Aberdeen | Noxubee County | ||
| October 8 | Biggersville | Hatley | at Amory | ||
| October 15 | at Falkner | at Noxubee County | Nettleton | ||
| October 22 | H.W. Byers | at Aberdeen | |||
| October 29 | at TCPS | Nettleton | Kossuth | ||
| November 1 | Thrasher |
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